Super enhancer-mediated upregulation of HJURP promotes growth and survival of t(4;14)-positive multiple myeloma

• Main Authors: Jia, Yunlu, Zhou, Jianbiao, Tan, Tze King, Chung, Tae-Hoon, Chen, Yongxia, Chooi, Jing-Yuan, Sanda, Takaomi, Fullwood, Melissa Jane, Xiong, Sinan, Toh, Sabrina H. M., Balan, Kalpnaa, Wong, Regina W. J., Lim, Julia S. L., Zhang, Enfan, Cai, Zhen, Shen, Peng, Chng, Wee Joo
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Science::Medicine; Carcinogenesis; Apoptosis
• Online Access: https://hdl.handle.net/10356/162509
• Institution: Nanyang Technological University

Multiple myeloma is an incurable malignancy with marked clinical and genetic heterogeneity. The cytogenetic abnormality t(4;14) (p16.3;q32.3) confers aggressive behavior in multiple myeloma. Recently, essential oncogenic drivers in a wide range of cancers have been shown to be controlled by super-en...