The unfolded protein response reverses the effects of glucose on lifespan in chemically-sterilized C. elegans

• Main Authors: Beaudoin-Chabot, Caroline, Wang, Lei, Celik, Cenk, Aishah Tul-Firdaus Abdul Khalid, Thalappilly, Subhash, Xu, Shiyi, Koh, Jhee Hong, Lim, Venus Wen Xuan, Low, Ann Don, Thibault, Guillaume
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Ageing; Stress
• Online Access: https://hdl.handle.net/10356/162675
• Institution: Nanyang Technological University

Metabolic diseases often share common traits, including accumulation of unfolded proteins in the endoplasmic reticulum (ER). Upon ER stress, the unfolded protein response (UPR) is activated to limit cellular damage which weakens with age. Here, we show that Caenorhabditis elegans fed a bacterial die...