Lipid bilayer stress-activated IRE-1 modulates autophagy during endoplasmic reticulum stress

• Main Authors: Koh, Jhee Hong, Wang, Lei, Beaudoin-Chabot, Caroline, Thibault, Guillaume
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Endoplasmic Reticulum (ER); Unfolded Protein Response (UPR); DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/89666; http://hdl.handle.net/10220/46714; https://doi.org/10.21979/N9/OLY1FU
• Institution: Nanyang Technological University

Metabolic disorders such as nonalcoholic fatty liver disease (NAFLD) are emerging epidemics that affect the global population. One facet of these disorders is attributed to the disturbance of membrane lipid composition. Perturbation of endoplasmic reticulum (ER) homeostasis through alteration in mem...