ZRSR1 co-operates with ZRSR2 in regulating splicing of U12-type introns in murine hematopoietic cells

• Main Authors: Madan, Vikas, Cao, Zeya, Teoh, Weoi Woon, Dakle, Pushkar, Han, Lin, Shyamsunder, Pavithra, Jeitany, Maya, Zhou, Siqin, Li, Jia, Hazimah Mohd Nordin, Shi, JiZhong, Yu, Shuizhou, Yang, Henry, Md Zakir Hossain, Chng, Wee Joo, Koeffler, H Phillip
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Protein P53; Hematopoietic Cell
• Online Access: https://hdl.handle.net/10356/162693
• Institution: Nanyang Technological University

Recurrent loss-of-function mutations of spliceosome gene, ZRSR2, occur in myelodysplastic syndromes (MDS). Mutation/loss of ZRSR2 in human myeloid cells primarily causes impaired splicing of the U12-type introns. In order to further investigate the role of this splice factor in RNA splicing and hema...