SARS-CoV-2 non-structural protein 6 triggers NLRP3-dependent pyroptosis by targeting ATP6AP1

• Main Authors: Sun, Xiao, Liu, Yingzhi, Huang, Ziheng, Xu, Wenye, Hu, Wei, Yi, Lina, Liu, Zhe, Chan, Hung, Zeng, Judeng, Liu, Xiaodong, Chen, Huarong, Yu, Jun, Chan, Francis Ka Leung, Ng, Siew Chien, Wong, Sunny Hei, Wang, Maggie Haitian, Gin, Tony, Joynt, Gavin Matthew, Hui, David Shu Cheong, Zou, Xuan, Shu, Yuelong, Cheng, Christopher Hon Ki, Fang, Shisong, Luo, Huanle, Lu, Jing, Chan, Matthew Tak Vai, Zhang, Lin, Wu, William Ka Kei
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; ATP6AP1 Protein; Cryopyrin
• Online Access: https://hdl.handle.net/10356/162774
• Institution: Nanyang Technological University

A recent mutation analysis suggested that Non-Structural Protein 6 (NSP6) of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a key determinant of the viral pathogenicity. Here, by transcriptome analysis, we demonstrated that the inflammasome-related NOD-like receptor signaling wa...