Charge-reversal polymer nano-modulators for photodynamic immunotherapy of cancer

• Main Authors: He, Shasha, Li, Jingchao, Cheng, Penghui, Zeng, Ziling, Zhang, Chi, Duan, Hongwei, Pu, Kanyi
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2022
• Subjects: Engineering::Bioengineering; Science::Chemistry; Cancer Therapy; Tumor Penetration
• Online Access: https://hdl.handle.net/10356/162814
• Institution: Nanyang Technological University

Nanomedicine can regulate the balance between cytotoxic T lymphocytes (CTLs) and suppressive regulatory T lymphocytes (Tregs), which however has been rarely exploited for cancer immunotherapy. We report a charge-reversal polymer nano-modulator (SPDMC N) activated by tumor microenvironment (TME) for...