Transformable nanosensitizer with tumor microenvironment-activated sonodynamic process and calcium release for enhanced cancer immunotherapy

• Main Authors: Tan, Xuan, Huang, Jingzhao, Wang, Yiqian, He, Shasha, Jia, Le, Zhu, Yanhong, Pu, Kanyi, Zhang, Yan, Yang, Xiangliang
• 其他作者: School of Chemical and Biomedical Engineering
• 格式: Article
• 語言: English
• 出版: 2022
• 主題: Engineering::Chemical engineering; Cancer Sono-Immunotherapy; Immune Checkpoint Blockade
• 在線閱讀: https://hdl.handle.net/10356/162866

Despite the promise of sonodynamic processes in cancer therapy, existing sonosensitizers often fail to regulate the generation of reactive oxygen species (ROS) against tumors, potentially leading to off-target toxicity to normal tissues. We report a transformable core-shell nanosonosensitizer (TiO2...