Transformable nanosensitizer with tumor microenvironment-activated sonodynamic process and calcium release for enhanced cancer immunotherapy

• Main Authors: Tan, Xuan, Huang, Jingzhao, Wang, Yiqian, He, Shasha, Jia, Le, Zhu, Yanhong, Pu, Kanyi, Zhang, Yan, Yang, Xiangliang
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2022
• Subjects: Engineering::Chemical engineering; Cancer Sono-Immunotherapy; Immune Checkpoint Blockade
• Online Access: https://hdl.handle.net/10356/162866
• Institution: Nanyang Technological University

Despite the promise of sonodynamic processes in cancer therapy, existing sonosensitizers often fail to regulate the generation of reactive oxygen species (ROS) against tumors, potentially leading to off-target toxicity to normal tissues. We report a transformable core-shell nanosonosensitizer (TiO2...