Blocking CTLA-4 while priming with a whole cell vaccine reshapes the oligoclonal T cell infiltrate and eradicates tumors in an orthotopic glioma model

Blocking CTLA-4 while priming with a whole cell vaccine reshapes the oligoclonal T cell infiltrate and eradicates tumors in an orthotopic glioma model

Vaccine-mediated cancer treatment is unlikely to induce long-term survival unless suppressive mechanisms are overcome. Given the success of antibody-mediated immune checkpoint blockade in relieving regulation of endogenous anti-tumor T cell responses in tumor-burdened hosts, we investigated whether...

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Bibliographic Details
Main Authors: Field, Cameron S., Hunn, Martin K., Ferguson, Peter M., Ruedl, Christiane, Ancelet, Lindsay R., Hermans, Ian F.
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2019
Subjects:
Vaccine
Checkpoint Blockade
Science::Biological sciences
Online Access:https://hdl.handle.net/10356/85533
http://hdl.handle.net/10220/49233
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/85533
http://hdl.handle.net/10220/49233

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