Blocking CTLA-4 while priming with a whole cell vaccine reshapes the oligoclonal T cell infiltrate and eradicates tumors in an orthotopic glioma model

• Main Authors: Field, Cameron S., Hunn, Martin K., Ferguson, Peter M., Ruedl, Christiane, Ancelet, Lindsay R., Hermans, Ian F.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Vaccine; Checkpoint Blockade; Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/85533; http://hdl.handle.net/10220/49233
• Institution: Nanyang Technological University

Vaccine-mediated cancer treatment is unlikely to induce long-term survival unless suppressive mechanisms are overcome. Given the success of antibody-mediated immune checkpoint blockade in relieving regulation of endogenous anti-tumor T cell responses in tumor-burdened hosts, we investigated whether...