Standing on the shoulders of giant : small membrane molecules that associate laterally with integrins.
A mode of integrins modulation is lately gaining acceptance and increasingly studied is: how the type of adhesion and signalling following integrins ligation may be modulated by lateral association with other membrane molecules.This review paper will elaborate more on some of these components that...
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| Format: | Final Year Project |
| Language: | English |
| Published: |
2009
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| Subjects: | |
| Online Access: | http://hdl.handle.net/10356/16294 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | A mode of integrins modulation is lately gaining acceptance and increasingly
studied is: how the type of adhesion and signalling following integrins ligation may
be modulated by lateral association with other membrane molecules.This review paper will elaborate more on some of these components that interact
laterally with integrins and provide modulatory function. Since the discovery of
complement receptor- 3 (CR3/αMβ2)- FcIIIB interaction, the number of integrinassociated
partner proteins has grown dramatically in the past decade to about 20
(Table 2). They can be classified into two major classes being transmembrane (~7
members) and glycosylphosphatidylinositol (GPI)- linked (~5 members). The rest are
receptors, transporters, adherence proteins and channels. |
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