Standing on the shoulders of giant : small membrane molecules that associate laterally with integrins.

• Main Author: Wong, Alvin Yao Sheng.
• Other Authors: Tan Suet Mien
• Format: Final Year Project
• Language: English
• Published: 2009
• Subjects: DRNTU::Science::Biological sciences::Molecular biology
• Online Access: http://hdl.handle.net/10356/16294
• Institution: Nanyang Technological University

A mode of integrins modulation is lately gaining acceptance and increasingly studied is: how the type of adhesion and signalling following integrins ligation may be modulated by lateral association with other membrane molecules.This review paper will elaborate more on some of these components that interact laterally with integrins and provide modulatory function. Since the discovery of complement receptor- 3 (CR3/αMβ2)- FcIIIB interaction, the number of integrinassociated partner proteins has grown dramatically in the past decade to about 20 (Table 2). They can be classified into two major classes being transmembrane (~7 members) and glycosylphosphatidylinositol (GPI)- linked (~5 members). The rest are receptors, transporters, adherence proteins and channels.