The structural basis of β2 integrin intra-cellular multi-protein complexes

In multicellular organisms, cell adhesion is a pivotal physiological process which is essential for cell-cell communications, cell migration, and interactions with extracellular matrix. Integrins, a family of large hetero-dimeric type I membrane proteins, are known for driving cell adhesion function...

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Main Author: Bhattacharjya, Surajit
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2022
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Online Access:https://hdl.handle.net/10356/163062
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1630622023-02-28T17:11:13Z The structural basis of β2 integrin intra-cellular multi-protein complexes Bhattacharjya, Surajit School of Biological Sciences Science::Biological sciences Integrins β2 integrins In multicellular organisms, cell adhesion is a pivotal physiological process which is essential for cell-cell communications, cell migration, and interactions with extracellular matrix. Integrins, a family of large hetero-dimeric type I membrane proteins, are known for driving cell adhesion functions. Among 24 different integrins, four β2 integrins, αL β2, αM β2, αX β2 and αD β2, are specific for cell adhesion and migration of leukocytes. Many cytosolic proteins interact with short cytosolic tails (CTs) of β2 and other integrins which are essential in bi-directional signaling processes. Further, phosphorylation of CTs of integrins regulates binding of intra-cellular proteins and signaling systems. In this review, recent advances in structures and interactions of multi-protein complexes of integrin tails, with a focus on β2 integrin, and cytosolic proteins are discussed along with a proposed future direction. Ministry of Education (MOE) Submitted/Accepted version Studies of integrins are support by grants from Biomedical Research Council (BMRC), Singapore and Ministry of Education (MOE), Singapore. 2022-11-18T03:41:11Z 2022-11-18T03:41:11Z 2022 Journal Article Bhattacharjya, S. (2022). The structural basis of β2 integrin intra-cellular multi-protein complexes. Biophysical Reviews, 14(5), 1183-1195. https://dx.doi.org/10.1007/s12551-022-00995-x 1867-2450 https://hdl.handle.net/10356/163062 10.1007/s12551-022-00995-x 36345283 2-s2.0-85137457039 5 14 1183 1195 en Biophysical Reviews © 2022 International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature. All rights reserved. This paper was published in Biophysical Reviews and is made available with permission of International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Biological sciences
Integrins
β2 integrins
spellingShingle Science::Biological sciences
Integrins
β2 integrins
Bhattacharjya, Surajit
The structural basis of β2 integrin intra-cellular multi-protein complexes
description In multicellular organisms, cell adhesion is a pivotal physiological process which is essential for cell-cell communications, cell migration, and interactions with extracellular matrix. Integrins, a family of large hetero-dimeric type I membrane proteins, are known for driving cell adhesion functions. Among 24 different integrins, four β2 integrins, αL β2, αM β2, αX β2 and αD β2, are specific for cell adhesion and migration of leukocytes. Many cytosolic proteins interact with short cytosolic tails (CTs) of β2 and other integrins which are essential in bi-directional signaling processes. Further, phosphorylation of CTs of integrins regulates binding of intra-cellular proteins and signaling systems. In this review, recent advances in structures and interactions of multi-protein complexes of integrin tails, with a focus on β2 integrin, and cytosolic proteins are discussed along with a proposed future direction.
author2 School of Biological Sciences
author_facet School of Biological Sciences
Bhattacharjya, Surajit
format Article
author Bhattacharjya, Surajit
author_sort Bhattacharjya, Surajit
title The structural basis of β2 integrin intra-cellular multi-protein complexes
title_short The structural basis of β2 integrin intra-cellular multi-protein complexes
title_full The structural basis of β2 integrin intra-cellular multi-protein complexes
title_fullStr The structural basis of β2 integrin intra-cellular multi-protein complexes
title_full_unstemmed The structural basis of β2 integrin intra-cellular multi-protein complexes
title_sort structural basis of β2 integrin intra-cellular multi-protein complexes
publishDate 2022
url https://hdl.handle.net/10356/163062
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