A multi-regression framework to improve diagnostic ability of optical coherence tomography retinal biomarkers to discriminate mild cognitive impairment and Alzheimer's disease

• Main Authors: Chua, Jacqueline, Li, Chi, Ho, Lucius Kang Hua, Wong, Damon, Tan, Bingyao, Yao, Xinwen, Gan, Alfred, Schwarzhans, Florian, Garhöfer, Gerhard, Sng, Chelvin C. A., Hilal, Saima, Venketasubramanian, Narayanaswamy, Cheung, Carol Y., Fischer, Georg, Vass, Clemens, Wong, Tien Yin, Chen, Christopher Li-Hsian, Schmetterer, Leopold
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2022
• Subjects: Engineering::Bioengineering; Optical Coherence Tomography; Mild Cognitive Impairment
• Online Access: https://hdl.handle.net/10356/163081
• Institution: Nanyang Technological University

Background: Diagnostic performance of optical coherence tomography (OCT) to detect Alzheimer’s disease (AD) and mild cognitive impairment (MCI) remains limited. We assessed whether compensating the circumpapillary retinal nerve fiber layer (cpRNFL) thickness for multiple demographic and anatomical f...