Insights into POT1 structural dynamics revealed by cryo-EM

• Main Authors: Smith, Emmanuel W., Lattmann, Simon, Liu, Barry Zhehui, Ahsan, Bilal, Rhodes, Daniela
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Oligonucleotide; Binding Affinity
• Online Access: https://hdl.handle.net/10356/163095
• Institution: Nanyang Technological University

Telomeres are protein-DNA complexes that protect the ends of linear eukaryotic chromosomes. Mammalian telomeric DNA consists of 5'-(TTAGGG)n-3' double-stranded repeats, followed by up to several hundred bases of a 3' single-stranded G-rich overhang. The G-rich overhang is bound by the...