Transcriptome profiling of osteoblasts in a medaka (oryzias latipes) osteoporosis model identifies mmp13b as crucial for osteoclast activation

• Main Authors: Liu, Ranran, Imangali, Nurgul, Ethiraj, Lalith P., Carney, Tom J., Winkler, Christoph
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Osteoblasts; Matrix Metalloprotease
• Online Access: https://hdl.handle.net/10356/163184
• Institution: Nanyang Technological University

Matrix metalloproteases (MMPs) play crucial roles in extracellular matrix (ECM) modulation during osteoclast-driven bone remodeling. In the present study, we used transcriptome profiling of bone cells in a medaka model for osteoporosis and bone regeneration to identify factors critical for bone remo...