Robust delivery of RIG-I agonists using extracellular vesicles for anti-cancer immunotherapy

• المؤلفون الرئيسيون: Peng, Boya, Nguyen, Trinh Mai, Jayasinghe, Migara Kavishka, Gao, Chang, Pham, Thach Tuan, Vu, Luyen Tien, Yeo, Eric Yew Meng, Yap, Gracemary, Wang, Lingzhi, Goh, Boon Cher, Tam, Wai Leong, Luo, Dahai, Le, Minh TN
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2022
• الموضوعات: Science::Medicine; Cancer; Extracellular Vesicles,
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/163208

The RIG-I pathway can be activated by RNA containing 5' triphosphate, leading to type I interferon release and immune activation. Hence, RIG-I agonists have been used to induce immune responses against cancer as potential immunotherapy. However, delivery of 5' triphosphorylated RNA molecul...