Src activates retrograde membrane traffic through phosphorylation of GBF1

• المؤلفون الرئيسيون: Chia, Joanne, Wang, Shyi-Chyi, Wee, Sheena, Gill, David James, Tay, Felicia, Kannan, Srinivasaraghavan, Verma, Chandra Shekhar, Gunaratne, Jayantha, Bard, Frederic A.
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2022
• الموضوعات: Science::Biological sciences; Membrane Traffic; Signalling
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/163234

The Src tyrosine kinase controls cancer-critical protein glycosylation through Golgi to ER relocation of GALNTs enzymes. How Src induces this trafficking event is unknown. Golgi to ER transport depends on the GTP exchange factor (GEF) GBF1 and small GTPase Arf1. Here, we show that Src induces the fo...