Src activates retrograde membrane traffic through phosphorylation of GBF1

• Main Authors: Chia, Joanne, Wang, Shyi-Chyi, Wee, Sheena, Gill, David James, Tay, Felicia, Kannan, Srinivasaraghavan, Verma, Chandra Shekhar, Gunaratne, Jayantha, Bard, Frederic A.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Membrane Traffic; Signalling
• Online Access: https://hdl.handle.net/10356/163234
• Institution: Nanyang Technological University

The Src tyrosine kinase controls cancer-critical protein glycosylation through Golgi to ER relocation of GALNTs enzymes. How Src induces this trafficking event is unknown. Golgi to ER transport depends on the GTP exchange factor (GEF) GBF1 and small GTPase Arf1. Here, we show that Src induces the fo...