A promising deep learning-assistive algorithm for histopathological screening of colorectal cancer

Colorectal cancer is one of the most common cancers worldwide, accounting for an annual estimated 1.8 million incident cases. With the increasing number of colonoscopies being performed, colorectal biopsies make up a large proportion of any histopathology laboratory workload. We trained and validate...

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Main Authors: Ho, Cowan, Zhao, Zitong, Chen, Xiu Fen, Sauer, Jan, Saraf, Sahil Ajit, Jialdasani, Rajasa, Taghipour, Kaveh, Sathe, Aneesh, Khor, Li-Yan, Lim, Kiat-Hon, Leow, Wei-Qiang
Other Authors: School of Biological Sciences
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Language:English
Published: 2022
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Online Access:https://hdl.handle.net/10356/163278
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Institution: Nanyang Technological University
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spelling sg-ntu-dr.10356-1632782023-02-28T17:12:49Z A promising deep learning-assistive algorithm for histopathological screening of colorectal cancer Ho, Cowan Zhao, Zitong Chen, Xiu Fen Sauer, Jan Saraf, Sahil Ajit Jialdasani, Rajasa Taghipour, Kaveh Sathe, Aneesh Khor, Li-Yan Lim, Kiat-Hon Leow, Wei-Qiang School of Biological Sciences Singapore General Hospital Duke-NUS Medical School Science::Biological sciences Science::Medicine Colorectal Tumor Computer Assisted Diagnosis Colorectal cancer is one of the most common cancers worldwide, accounting for an annual estimated 1.8 million incident cases. With the increasing number of colonoscopies being performed, colorectal biopsies make up a large proportion of any histopathology laboratory workload. We trained and validated a unique artificial intelligence (AI) deep learning model as an assistive tool to screen for colonic malignancies in colorectal specimens, in order to improve cancer detection and classification; enabling busy pathologists to focus on higher order decision-making tasks. The study cohort consists of Whole Slide Images (WSI) obtained from 294 colorectal specimens. Qritive's unique composite algorithm comprises both a deep learning model based on a Faster Region Based Convolutional Neural Network (Faster-RCNN) architecture for instance segmentation with a ResNet-101 feature extraction backbone that provides glandular segmentation, and a classical machine learning classifier. The initial training used pathologists' annotations on a cohort of 66,191 image tiles extracted from 39 WSIs. A subsequent application of a classical machine learning-based slide classifier sorted the WSIs into 'low risk' (benign, inflammation) and 'high risk' (dysplasia, malignancy) categories. We further trained the composite AI-model's performance on a larger cohort of 105 resections WSIs and then validated our findings on a cohort of 150 biopsies WSIs against the classifications of two independently blinded pathologists. We evaluated the area under the receiver-operator characteristic curve (AUC) and other performance metrics. The AI model achieved an AUC of 0.917 in the validation cohort, with excellent sensitivity (97.4%) in detection of high risk features of dysplasia and malignancy. We demonstrate an unique composite AI-model incorporating both a glandular segmentation deep learning model and a classical machine learning classifier, with excellent sensitivity in picking up high risk colorectal features. As such, AI plays a role as a potential screening tool in assisting busy pathologists by outlining the dysplastic and malignant glands. Published version 2022-11-30T02:09:14Z 2022-11-30T02:09:14Z 2022 Journal Article Ho, C., Zhao, Z., Chen, X. F., Sauer, J., Saraf, S. A., Jialdasani, R., Taghipour, K., Sathe, A., Khor, L., Lim, K. & Leow, W. (2022). A promising deep learning-assistive algorithm for histopathological screening of colorectal cancer. Scientific Reports, 12(1), 2222-. https://dx.doi.org/10.1038/s41598-022-06264-x 2045-2322 https://hdl.handle.net/10356/163278 10.1038/s41598-022-06264-x 35140318 2-s2.0-85124270338 1 12 2222 en Scientific Reports © The Author(s) 2022. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Biological sciences
Science::Medicine
Colorectal Tumor
Computer Assisted Diagnosis
spellingShingle Science::Biological sciences
Science::Medicine
Colorectal Tumor
Computer Assisted Diagnosis
Ho, Cowan
Zhao, Zitong
Chen, Xiu Fen
Sauer, Jan
Saraf, Sahil Ajit
Jialdasani, Rajasa
Taghipour, Kaveh
Sathe, Aneesh
Khor, Li-Yan
Lim, Kiat-Hon
Leow, Wei-Qiang
A promising deep learning-assistive algorithm for histopathological screening of colorectal cancer
description Colorectal cancer is one of the most common cancers worldwide, accounting for an annual estimated 1.8 million incident cases. With the increasing number of colonoscopies being performed, colorectal biopsies make up a large proportion of any histopathology laboratory workload. We trained and validated a unique artificial intelligence (AI) deep learning model as an assistive tool to screen for colonic malignancies in colorectal specimens, in order to improve cancer detection and classification; enabling busy pathologists to focus on higher order decision-making tasks. The study cohort consists of Whole Slide Images (WSI) obtained from 294 colorectal specimens. Qritive's unique composite algorithm comprises both a deep learning model based on a Faster Region Based Convolutional Neural Network (Faster-RCNN) architecture for instance segmentation with a ResNet-101 feature extraction backbone that provides glandular segmentation, and a classical machine learning classifier. The initial training used pathologists' annotations on a cohort of 66,191 image tiles extracted from 39 WSIs. A subsequent application of a classical machine learning-based slide classifier sorted the WSIs into 'low risk' (benign, inflammation) and 'high risk' (dysplasia, malignancy) categories. We further trained the composite AI-model's performance on a larger cohort of 105 resections WSIs and then validated our findings on a cohort of 150 biopsies WSIs against the classifications of two independently blinded pathologists. We evaluated the area under the receiver-operator characteristic curve (AUC) and other performance metrics. The AI model achieved an AUC of 0.917 in the validation cohort, with excellent sensitivity (97.4%) in detection of high risk features of dysplasia and malignancy. We demonstrate an unique composite AI-model incorporating both a glandular segmentation deep learning model and a classical machine learning classifier, with excellent sensitivity in picking up high risk colorectal features. As such, AI plays a role as a potential screening tool in assisting busy pathologists by outlining the dysplastic and malignant glands.
author2 School of Biological Sciences
author_facet School of Biological Sciences
Ho, Cowan
Zhao, Zitong
Chen, Xiu Fen
Sauer, Jan
Saraf, Sahil Ajit
Jialdasani, Rajasa
Taghipour, Kaveh
Sathe, Aneesh
Khor, Li-Yan
Lim, Kiat-Hon
Leow, Wei-Qiang
format Article
author Ho, Cowan
Zhao, Zitong
Chen, Xiu Fen
Sauer, Jan
Saraf, Sahil Ajit
Jialdasani, Rajasa
Taghipour, Kaveh
Sathe, Aneesh
Khor, Li-Yan
Lim, Kiat-Hon
Leow, Wei-Qiang
author_sort Ho, Cowan
title A promising deep learning-assistive algorithm for histopathological screening of colorectal cancer
title_short A promising deep learning-assistive algorithm for histopathological screening of colorectal cancer
title_full A promising deep learning-assistive algorithm for histopathological screening of colorectal cancer
title_fullStr A promising deep learning-assistive algorithm for histopathological screening of colorectal cancer
title_full_unstemmed A promising deep learning-assistive algorithm for histopathological screening of colorectal cancer
title_sort promising deep learning-assistive algorithm for histopathological screening of colorectal cancer
publishDate 2022
url https://hdl.handle.net/10356/163278
_version_ 1759858298684702720