Hom-complex-based machine learning (HCML) for the prediction of protein–protein binding affinity changes upon mutation

• Main Authors: Liu, Xiang, Feng, Huitao, Wu, Jie, Xia, Kelin
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Mathematics; Artificial Intelligence; Biological Process
• Online Access: https://hdl.handle.net/10356/163436
• Institution: Nanyang Technological University

Protein-protein interactions (PPIs) are involved in almost all biological processes in the cell. Understanding protein-protein interactions holds the key for the understanding of biological functions, diseases and the development of therapeutics. Recently, artificial intelligence (AI) models have de...