HBx and HCV core, viral proteins associated with hepatocarcinoma, promote N-CoR degradation.

• Main Author: Haris.
• Other Authors: School of Biological Sciences
• Format: Final Year Project
• Language: English
• Published: 2009
• Subjects: DRNTU::Science::Biological sciences::Molecular biology
• Online Access: http://hdl.handle.net/10356/16348
• Institution: Nanyang Technological University

Hepatocellular carcinoma (HCC) is frequently found in patients with chronic infection of either hepatitis B- or C- virus (HBV or HCV). However, the precise mechanism of how these viral proteins are involved in hepatocarcinogenesis remains unknown. The nuclear receptor co-repressor (N-CoR) and other...