Carbene-catalyzed activation of C-Si bonds for chemo- and enantioselective cross Brook–Benzoin reaction

The first carbene-catalyzed asymmetric chemoselective cross silyl benzoin (Brook-Benzoin) reaction has been developed. Key steps of this reaction involve activation of the carbon-silicon bond of an acylsilane by a chiral N-heterocyclic carbene (NHC) catalyst to form a silyl acyl anion intermediate....

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Main Authors: Tang, Chenghao, Wang, Wei, Luo, Guoyong, Song, Chaoyang, Bao, Zhaowei, Li, Pei, Hao, Gefei, Chi, Robin Yonggui, Jin, Zhichao
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2022
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Online Access:https://hdl.handle.net/10356/163498
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Institution: Nanyang Technological University
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spelling sg-ntu-dr.10356-1634982022-12-07T08:30:14Z Carbene-catalyzed activation of C-Si bonds for chemo- and enantioselective cross Brook–Benzoin reaction Tang, Chenghao Wang, Wei Luo, Guoyong Song, Chaoyang Bao, Zhaowei Li, Pei Hao, Gefei Chi, Robin Yonggui Jin, Zhichao School of Physical and Mathematical Sciences Science::Chemistry Acylsilanes Benzoin Condensation The first carbene-catalyzed asymmetric chemoselective cross silyl benzoin (Brook-Benzoin) reaction has been developed. Key steps of this reaction involve activation of the carbon-silicon bond of an acylsilane by a chiral N-heterocyclic carbene (NHC) catalyst to form a silyl acyl anion intermediate. These acyl anions then undergo an addition reaction with indole aldehydes in a highly chemo- and enantioselective manner to afford α-silyloxy ketones with excellent optical purities. The reaction mechanism of this cross Brook-Benzoin reaction was investigated through both experimental and computational methods. The chiral α-hydroxy ketone derivatives obtained by this approach show promising, agrochemically interesting activity against harmful plant bacteria. Agency for Science, Technology and Research (A*STAR) Ministry of Education (MOE) Nanyang Technological University National Research Foundation (NRF) We acknowledge financial support from the Qiandongnan Science and Technology Plan Project (Qiandongnan kehejichu [2021]17), the Youth Science and Technology Talent Growth Program of Guizhou Province's Department of Education (Qian Jiaohe KY [2022]074), the National Natural Science Foundation of China (21961006, 22071036, 32172459), The 10 Talent Plan (Shicengci) of Guizhou Province ([2016]5649), the Science and Technology Department of Guizhou Province ([2019]1020, Qiankehejichu-ZK[2021]Key033), the Program of Introducing Talents of Discipline to Universities of China (111 Program, D20023) at Guizhou University, Frontiers Science Center for Asymmetric Synthesis and Medicinal Molecules, Department of Education, Guizhou Province [Qianjiaohe KY (2020)004], the Basic and Applied Research Foundation of Guangdong Province (2019A1515110906), the Guizhou Province First-Class Disciplines Project [(Yiliu Xueke Jianshe Xiangmu)-GNYL(2017)008], Guizhou University of Traditional Chinese Medicine, and Guizhou University (China). Singapore National Research Foundation under its NRF Investigatorship (NRF-NRFI2016-06), the Ministry of Education, Singapore, under its MOE AcRF Tier 1 Award (RG108/16, RG5/19, RG1/18), MOE AcRF Tier 3 Award (MOE2018-T3-1-003), the Agency for Science, Technology and Research (A*STAR) under its A*STAR AME IRG Award (A1783c0008, A1783c0010), GSK-EDB Trust Fund, Nanyang Research Award Grant, Nanyang Technological University. 2022-12-07T08:30:14Z 2022-12-07T08:30:14Z 2022 Journal Article Tang, C., Wang, W., Luo, G., Song, C., Bao, Z., Li, P., Hao, G., Chi, R. Y. & Jin, Z. (2022). Carbene-catalyzed activation of C-Si bonds for chemo- and enantioselective cross Brook–Benzoin reaction. Angewandte Chemie International Edition, 61(34), e202206961-. https://dx.doi.org/10.1002/anie.202206961 1433-7851 https://hdl.handle.net/10356/163498 10.1002/anie.202206961 35696352 2-s2.0-85133598846 34 61 e202206961 en NRF-NRFI2016-06 RG108/16 RG5/19 RG1/18 MOE2018-T3-1-003 A1783c0008 A1783c0010 Angewandte Chemie International Edition © 2022 Wiley-VCH GmbH. All rights reserved.
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Chemistry
Acylsilanes
Benzoin Condensation
spellingShingle Science::Chemistry
Acylsilanes
Benzoin Condensation
Tang, Chenghao
Wang, Wei
Luo, Guoyong
Song, Chaoyang
Bao, Zhaowei
Li, Pei
Hao, Gefei
Chi, Robin Yonggui
Jin, Zhichao
Carbene-catalyzed activation of C-Si bonds for chemo- and enantioselective cross Brook–Benzoin reaction
description The first carbene-catalyzed asymmetric chemoselective cross silyl benzoin (Brook-Benzoin) reaction has been developed. Key steps of this reaction involve activation of the carbon-silicon bond of an acylsilane by a chiral N-heterocyclic carbene (NHC) catalyst to form a silyl acyl anion intermediate. These acyl anions then undergo an addition reaction with indole aldehydes in a highly chemo- and enantioselective manner to afford α-silyloxy ketones with excellent optical purities. The reaction mechanism of this cross Brook-Benzoin reaction was investigated through both experimental and computational methods. The chiral α-hydroxy ketone derivatives obtained by this approach show promising, agrochemically interesting activity against harmful plant bacteria.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Tang, Chenghao
Wang, Wei
Luo, Guoyong
Song, Chaoyang
Bao, Zhaowei
Li, Pei
Hao, Gefei
Chi, Robin Yonggui
Jin, Zhichao
format Article
author Tang, Chenghao
Wang, Wei
Luo, Guoyong
Song, Chaoyang
Bao, Zhaowei
Li, Pei
Hao, Gefei
Chi, Robin Yonggui
Jin, Zhichao
author_sort Tang, Chenghao
title Carbene-catalyzed activation of C-Si bonds for chemo- and enantioselective cross Brook–Benzoin reaction
title_short Carbene-catalyzed activation of C-Si bonds for chemo- and enantioselective cross Brook–Benzoin reaction
title_full Carbene-catalyzed activation of C-Si bonds for chemo- and enantioselective cross Brook–Benzoin reaction
title_fullStr Carbene-catalyzed activation of C-Si bonds for chemo- and enantioselective cross Brook–Benzoin reaction
title_full_unstemmed Carbene-catalyzed activation of C-Si bonds for chemo- and enantioselective cross Brook–Benzoin reaction
title_sort carbene-catalyzed activation of c-si bonds for chemo- and enantioselective cross brook–benzoin reaction
publishDate 2022
url https://hdl.handle.net/10356/163498
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