Nickel-catalyzed enantioselective reductive conjugate arylation and heteroarylation via an elementary mechanism of 1,4-addition

• المؤلفون الرئيسيون: Zhang, Luoqiang, Zhao, Mengxin, Pu, Maoping, Ma, Zhaoming, Zhou, Jingsong, Chen, Caiyou, Wu, Yun-Dong, Chi, Robin Yonggui, Zhou, Jianrong Steve
• مؤلفون آخرون: School of Chemical and Biomedical Engineering
• التنسيق: مقال
• اللغة: English
• منشور في: 2022
• الموضوعات: Science::Chemistry; Quaternary Stereogenic Centers; Arylboronic Acids
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/163722

A nickel complex of isoquinox promoted enantioselective conjugate arylation and heteroarylation of enones using aryl and heteroaryl halides directly. The reaction was successfully applied to stereoselective syntheses of ar-turmerone, chiral fragments of (+)-tolterodine and AZD5672. Mechanistically, experiments and calculations supported that an arylnickel(I) complex inserted to enones via an elementary 1,4-addition.