Palladium-Catalyzed Heteroarylation and Concomitant ortho-Alkylation of Aryl Iodides

• Main Authors: Lei, Chuanhu, Jin, Xiaojia, Zhou, Jianrong (Steve)
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2016
• Subjects: cross-coupling; heterocycles; palladium; C-H activation; synthetic method
• Online Access: https://hdl.handle.net/10356/80263; http://hdl.handle.net/10220/40514
• Institution: Nanyang Technological University

Three-component couplings were achieved from common aryl halides, alkyl halides, and heteroarenes under palladium and norbornene co-catalysis. The reaction forges hindered aryl–heteroaryl bonds and introduces ortho-alkyl groups to aryl rings. Various heterocycles such as oxazoles, thiazoles and thio...