Palladium-Catalyzed Heteroarylation and Concomitant ortho-Alkylation of Aryl Iodides

Three-component couplings were achieved from common aryl halides, alkyl halides, and heteroarenes under palladium and norbornene co-catalysis. The reaction forges hindered aryl–heteroaryl bonds and introduces ortho-alkyl groups to aryl rings. Various heterocycles such as oxazoles, thiazoles and thio...

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Main Authors: Lei, Chuanhu, Jin, Xiaojia, Zhou, Jianrong (Steve)
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2016
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Online Access:https://hdl.handle.net/10356/80263
http://hdl.handle.net/10220/40514
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-802632020-03-07T12:31:21Z Palladium-Catalyzed Heteroarylation and Concomitant ortho-Alkylation of Aryl Iodides Lei, Chuanhu Jin, Xiaojia Zhou, Jianrong (Steve) School of Physical and Mathematical Sciences cross-coupling heterocycles palladium C-H activation synthetic method Three-component couplings were achieved from common aryl halides, alkyl halides, and heteroarenes under palladium and norbornene co-catalysis. The reaction forges hindered aryl–heteroaryl bonds and introduces ortho-alkyl groups to aryl rings. Various heterocycles such as oxazoles, thiazoles and thiophenes underwent efficient coupling. The heteroarenes were deprotonated in situ by bases without the assistance of palladium catalysts. MOE (Min. of Education, S’pore) 2016-05-10T07:25:46Z 2019-12-06T13:46:06Z 2016-05-10T07:25:46Z 2019-12-06T13:46:06Z 2015 2015 Journal Article Lei, C., Jin, X., & Zhou, J. (2015). Palladium-Catalyzed Heteroarylation and Concomitant ortho-Alkylation of Aryl Iodides. Angewandte Chemie International Edition, 54(45), 13397-13400. 1433-7851 https://hdl.handle.net/10356/80263 http://hdl.handle.net/10220/40514 10.1002/anie.201507128 191130 en Angewandte Chemie International Edition © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. 4 p.
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic cross-coupling
heterocycles
palladium
C-H activation
synthetic method
spellingShingle cross-coupling
heterocycles
palladium
C-H activation
synthetic method
Lei, Chuanhu
Jin, Xiaojia
Zhou, Jianrong (Steve)
Palladium-Catalyzed Heteroarylation and Concomitant ortho-Alkylation of Aryl Iodides
description Three-component couplings were achieved from common aryl halides, alkyl halides, and heteroarenes under palladium and norbornene co-catalysis. The reaction forges hindered aryl–heteroaryl bonds and introduces ortho-alkyl groups to aryl rings. Various heterocycles such as oxazoles, thiazoles and thiophenes underwent efficient coupling. The heteroarenes were deprotonated in situ by bases without the assistance of palladium catalysts.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Lei, Chuanhu
Jin, Xiaojia
Zhou, Jianrong (Steve)
format Article
author Lei, Chuanhu
Jin, Xiaojia
Zhou, Jianrong (Steve)
author_sort Lei, Chuanhu
title Palladium-Catalyzed Heteroarylation and Concomitant ortho-Alkylation of Aryl Iodides
title_short Palladium-Catalyzed Heteroarylation and Concomitant ortho-Alkylation of Aryl Iodides
title_full Palladium-Catalyzed Heteroarylation and Concomitant ortho-Alkylation of Aryl Iodides
title_fullStr Palladium-Catalyzed Heteroarylation and Concomitant ortho-Alkylation of Aryl Iodides
title_full_unstemmed Palladium-Catalyzed Heteroarylation and Concomitant ortho-Alkylation of Aryl Iodides
title_sort palladium-catalyzed heteroarylation and concomitant ortho-alkylation of aryl iodides
publishDate 2016
url https://hdl.handle.net/10356/80263
http://hdl.handle.net/10220/40514
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