Palladium-Catalyzed Heteroarylation and Concomitant ortho-Alkylation of Aryl Iodides
Three-component couplings were achieved from common aryl halides, alkyl halides, and heteroarenes under palladium and norbornene co-catalysis. The reaction forges hindered aryl–heteroaryl bonds and introduces ortho-alkyl groups to aryl rings. Various heterocycles such as oxazoles, thiazoles and thio...
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sg-ntu-dr.10356-802632020-03-07T12:31:21Z Palladium-Catalyzed Heteroarylation and Concomitant ortho-Alkylation of Aryl Iodides Lei, Chuanhu Jin, Xiaojia Zhou, Jianrong (Steve) School of Physical and Mathematical Sciences cross-coupling heterocycles palladium C-H activation synthetic method Three-component couplings were achieved from common aryl halides, alkyl halides, and heteroarenes under palladium and norbornene co-catalysis. The reaction forges hindered aryl–heteroaryl bonds and introduces ortho-alkyl groups to aryl rings. Various heterocycles such as oxazoles, thiazoles and thiophenes underwent efficient coupling. The heteroarenes were deprotonated in situ by bases without the assistance of palladium catalysts. MOE (Min. of Education, S’pore) 2016-05-10T07:25:46Z 2019-12-06T13:46:06Z 2016-05-10T07:25:46Z 2019-12-06T13:46:06Z 2015 2015 Journal Article Lei, C., Jin, X., & Zhou, J. (2015). Palladium-Catalyzed Heteroarylation and Concomitant ortho-Alkylation of Aryl Iodides. Angewandte Chemie International Edition, 54(45), 13397-13400. 1433-7851 https://hdl.handle.net/10356/80263 http://hdl.handle.net/10220/40514 10.1002/anie.201507128 191130 en Angewandte Chemie International Edition © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. 4 p. |
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cross-coupling heterocycles palladium C-H activation synthetic method Lei, Chuanhu Jin, Xiaojia Zhou, Jianrong (Steve) Palladium-Catalyzed Heteroarylation and Concomitant ortho-Alkylation of Aryl Iodides |
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Three-component couplings were achieved from common aryl halides, alkyl halides, and heteroarenes under palladium and norbornene co-catalysis. The reaction forges hindered aryl–heteroaryl bonds and introduces ortho-alkyl groups to aryl rings. Various heterocycles such as oxazoles, thiazoles and thiophenes underwent efficient coupling. The heteroarenes were deprotonated in situ by bases without the assistance of palladium catalysts. |
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School of Physical and Mathematical Sciences |
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School of Physical and Mathematical Sciences Lei, Chuanhu Jin, Xiaojia Zhou, Jianrong (Steve) |
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Article |
author |
Lei, Chuanhu Jin, Xiaojia Zhou, Jianrong (Steve) |
author_sort |
Lei, Chuanhu |
title |
Palladium-Catalyzed Heteroarylation and Concomitant ortho-Alkylation of Aryl Iodides |
title_short |
Palladium-Catalyzed Heteroarylation and Concomitant ortho-Alkylation of Aryl Iodides |
title_full |
Palladium-Catalyzed Heteroarylation and Concomitant ortho-Alkylation of Aryl Iodides |
title_fullStr |
Palladium-Catalyzed Heteroarylation and Concomitant ortho-Alkylation of Aryl Iodides |
title_full_unstemmed |
Palladium-Catalyzed Heteroarylation and Concomitant ortho-Alkylation of Aryl Iodides |
title_sort |
palladium-catalyzed heteroarylation and concomitant ortho-alkylation of aryl iodides |
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2016 |
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https://hdl.handle.net/10356/80263 http://hdl.handle.net/10220/40514 |
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1681042209623769088 |