Nickel-catalyzed enantioselective reductive conjugate arylation and heteroarylation via an elementary mechanism of 1,4-addition

Nickel-catalyzed enantioselective reductive conjugate arylation and heteroarylation via an elementary mechanism of 1,4-addition

A nickel complex of isoquinox promoted enantioselective conjugate arylation and heteroarylation of enones using aryl and heteroaryl halides directly. The reaction was successfully applied to stereoselective syntheses of ar-turmerone, chiral fragments of (+)-tolterodine and AZD5672. Mechanistically,...

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Main Authors: Zhang, Luoqiang, Zhao, Mengxin, Pu, Maoping, Ma, Zhaoming, Zhou, Jingsong, Chen, Caiyou, Wu, Yun-Dong, Chi, Robin Yonggui, Zhou, Jianrong Steve
其他作者: School of Chemical and Biomedical Engineering
格式: Article
語言:English
出版: 2022
主題:
Science::Chemistry
Quaternary Stereogenic Centers
Arylboronic Acids
在線閱讀:https://hdl.handle.net/10356/163722
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總結:A nickel complex of isoquinox promoted enantioselective conjugate arylation and heteroarylation of enones using aryl and heteroaryl halides directly. The reaction was successfully applied to stereoselective syntheses of ar-turmerone, chiral fragments of (+)-tolterodine and AZD5672. Mechanistically, experiments and calculations supported that an arylnickel(I) complex inserted to enones via an elementary 1,4-addition.

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