Nickel-catalyzed enantioselective reductive conjugate arylation and heteroarylation via an elementary mechanism of 1,4-addition

• Main Authors: Zhang, Luoqiang, Zhao, Mengxin, Pu, Maoping, Ma, Zhaoming, Zhou, Jingsong, Chen, Caiyou, Wu, Yun-Dong, Chi, Robin Yonggui, Zhou, Jianrong Steve
• 其他作者: School of Chemical and Biomedical Engineering
• 格式: Article
• 語言: English
• 出版: 2022
• 主題: Science::Chemistry; Quaternary Stereogenic Centers; Arylboronic Acids
• 在線閱讀: https://hdl.handle.net/10356/163722
• 機構: Nanyang Technological University

A nickel complex of isoquinox promoted enantioselective conjugate arylation and heteroarylation of enones using aryl and heteroaryl halides directly. The reaction was successfully applied to stereoselective syntheses of ar-turmerone, chiral fragments of (+)-tolterodine and AZD5672. Mechanistically,...