Elevated c-di-GMP levels and expression of the type III secretion system promote corneal infection by Pseudomonas aeruginosa

• Main Authors: Yam, Joey Kuok Hoong, Aung, Thet Tun, Chua, Song Lin, Cheng, Yingying, Kohli, Gurjeet Singh, Zhou, Jianuan, Constancias, Florentin, Liu, Yang, Cai, Zhao, Salido, May Margarette, Drautz-Moses, Daniela Isabel, Rice, Scott A., Schuster, Stephan Christoph, Boo, Zhao Zhi, Wu, Bin, Kjelleberg, Staffan, Tolker-Nielsen, Tim, Lakshminarayanan, Rajamani, Beuerman, Roger W., Yang, Liang, Givskov, Michael
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Pseudomonas Aeruginosa; Transcriptomics
• Online Access: https://hdl.handle.net/10356/163875
• Institution: Nanyang Technological University

Pseudomonas aeruginosa is generally believed to establish biofilm-associated infections under the regulation of the secondary messenger c-di-GMP. To evaluate P. aeruginosa biofilm physiology during ocular infections, comparative transcriptomic analysis was performed on wild-type P. aeruginosa PAO1,...