Opposing effects on regulated insulin secretion of acute vs chronic stimulation of AMP-activated protein kinase

• Main Authors: Nguyen-Tu, Marie-Sophie, Harris, Joseph, Martinez-Sanchez, Aida, Chabosseau, Pauline, Hu, Ming, Georgiadou, Eleni, Pollard, Alice, Otero, Pablo, Lopez-Noriega, Livia, Leclerc, Isabelle, Sakamoto, Kei, Schmoll, Dieter, Smith, David M., Carling, David, Rutter, Guy A.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; AMP-Activated Protein Kinase; Insulin Secretion
• Online Access: https://hdl.handle.net/10356/163901
• Institution: Nanyang Technological University

Aims/hypothesis: Although targeted in extrapancreatic tissues by several drugs used to treat type 2 diabetes, the role of AMP-activated protein kinase (AMPK) in the control of insulin secretion is still debatable. Previous studies have used pharmacological activators of limited selectivity and speci...