MalariaCometChip for high-throughput quantification of DNA damage in Plasmodium falciparum

MalariaCometChip for high-throughput quantification of DNA damage in Plasmodium falciparum

Comet assay is a standard approach for studying DNA damage in malaria, but high-throughput options are not available. The CometChip was previously developed using mammalian cells as a high-throughput version of the comet assay. It is based on the same principle as the comet assay but provides greate...

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Bibliographic Details
Main Authors: Xiong, Aoli, Kaushal, Simran, Tay, Ian Junjie, Engelward, Bevin P., Han, Jongyoon, Preiser, Peter Rainer
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2023
Subjects:
Science::Biological sciences
High-Throughput Screening
Comet Assay
Online Access:https://hdl.handle.net/10356/164052
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Institution: Nanyang Technological University
Language: English
Description
Summary:Comet assay is a standard approach for studying DNA damage in malaria, but high-throughput options are not available. The CometChip was previously developed using mammalian cells as a high-throughput version of the comet assay. It is based on the same principle as the comet assay but provides greater efficacy, automated data processing, and improved consistency between experiments. In this protocol, we present MalariaCometChip to quantitatively assess drug-induced DNA damage in Plasmodium falciparum. For complete details on the use and execution of this protocol, please refer to Xiong et al. (2020).

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