UV-induced senescence of human dermal fibroblasts restrained by low-stiffness matrix by inhibiting NF-κB activation

• Main Authors: Yao, Xuefeng, Li, Huaqiong, Chen, Liping, Tan, Lay Poh
• Other Authors: School of Materials Science and Engineering
• Format: Article
• Language: English
• Published: 2023
• Subjects: Engineering::Materials; Human Dermal Fibroblasts; Matrix Stiffness
• Online Access: https://hdl.handle.net/10356/164055
• Institution: Nanyang Technological University

As a hallmark of skin aging, senescent human dermal fibroblasts (HDFs) are known to lose the ability to divide. However, they can still interact with their cellular environment and the surrounding matrix. As the skin ages, the progressive slowing down of HDFs function decreases the skin's struc...