Selective deletion of PPARβ/δ in fibroblasts causes dermal fibrosis by attenuated LRG1 expression

• Main Authors: Sng, Ming Keat, Chan, Jeremy Soon Kiat, Teo, Ziqiang, Phua, Terri, Tan, Eddie Han Pin, Wee, Jonathan Wei Kiat, Koh, Nikki Jun Ning, Tan, Chek Kun, Chen, Jia Peng, Pal, Mintu, Tong, Benny Meng Kiat, Tnay, Ya Lin, Ng, Xuan Rui, Zhu, Pengcheng, Chiba, Shunsuke, Wang, Xiaomeng, Wahli, Walter, Tan, Nguan Soon
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2018
• Subjects: Selective Deletion; Dermal Fibrosis
• Online Access: https://hdl.handle.net/10356/86650; http://hdl.handle.net/10220/45278
• Institution: Nanyang Technological University

Connective tissue diseases of the skin are characterized by excessive collagen deposition in the skin and internal organs. Fibroblasts play a pivotal role in the clinical presentation of these conditions. Nuclear receptor peroxisome-proliferator activated receptors (PPARs) are therapeutic targets fo...