UV-induced senescence of human dermal fibroblasts restrained by low-stiffness matrix by inhibiting NF-κB activation

• المؤلفون الرئيسيون: Yao, Xuefeng, Li, Huaqiong, Chen, Liping, Tan, Lay Poh
• مؤلفون آخرون: School of Materials Science and Engineering
• التنسيق: مقال
• اللغة: English
• منشور في: 2023
• الموضوعات: Engineering::Materials; Human Dermal Fibroblasts; Matrix Stiffness
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/164055

As a hallmark of skin aging, senescent human dermal fibroblasts (HDFs) are known to lose the ability to divide. However, they can still interact with their cellular environment and the surrounding matrix. As the skin ages, the progressive slowing down of HDFs function decreases the skin's struc...