Bioinspired stretchable molecular composites of 2D-layered materials and tandem repeat proteins

Protein based composites, such as nacre and bone, show astounding evolutionary capabilities, including tunable physical properties. Inspired by natural composites, we studied assembly of atomistically thin inorganic sheets with genetically engineered polymeric proteins to achieve mechanically compli...

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Main Authors: Vural, Mert, Mazeed, Tarek, Li, Dong, Colak, Oguzhan, Hamilton, Reginald F., Gao, Huajian, Demirel, Melik C.
Other Authors: School of Mechanical and Aerospace Engineering
Format: Article
Language:English
Published: 2023
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Online Access:https://hdl.handle.net/10356/164075
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Institution: Nanyang Technological University
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spelling sg-ntu-dr.10356-1640752023-01-04T03:37:47Z Bioinspired stretchable molecular composites of 2D-layered materials and tandem repeat proteins Vural, Mert Mazeed, Tarek Li, Dong Colak, Oguzhan Hamilton, Reginald F. Gao, Huajian Demirel, Melik C. School of Mechanical and Aerospace Engineering Engineering::Mechanical engineering 2D-Layered Materials Tandem Repeat Proteins Protein based composites, such as nacre and bone, show astounding evolutionary capabilities, including tunable physical properties. Inspired by natural composites, we studied assembly of atomistically thin inorganic sheets with genetically engineered polymeric proteins to achieve mechanically compliant and ultra-tough materials. Although bare inorganic nanosheets are brittle, we designed flexible composites with proteins, which are insensitive to flaws due to critical structural length scale (∼2 nm). These proteins, inspired by squid ring teeth, adhere to inorganic sheets via secondary structures (i.e., β-sheets and α-helices), which is essential for producing high stretchability (59 ± 1% fracture strain) and toughness (54.8 ± 2 MJ/m3). We find that the mechanical properties can be optimized by adjusting the protein molecular weight and tandem repetition. These exceptional mechanical responses greatly exceed the current state-of-the-art stretchability for layered composites by over a factor of three, demonstrating the promise of engineering materials with reconfigurable physical properties. Agency for Science, Technology and Research (A*STAR) Nanyang Technological University Published version M.V., T.M., O.C., and M.C.D. were partially supported by DARPA (D19AC00016), Airforce Office of Sponsored Research (FA9550-18-1-0235), Army Research Office (W911NF-16-1-0019), and Huck Endowment of Pennsylvania State University. D.L. and H.G. acknowledge a research start-up grant (002479-00001) from Nanyang Technological University and the Agency for Science, Technology and Research (A*STAR) and the use of the A*STAR Computational Resource Centre, Singapore (ACRC) and National Supercomputing Centre, Singapore (NSCC). 2023-01-04T03:37:47Z 2023-01-04T03:37:47Z 2022 Journal Article Vural, M., Mazeed, T., Li, D., Colak, O., Hamilton, R. F., Gao, H. & Demirel, M. C. (2022). Bioinspired stretchable molecular composites of 2D-layered materials and tandem repeat proteins. Proceedings of the National Academy of Sciences of the United States of America, 119(31), e2120021119-. https://dx.doi.org/10.1073/pnas.2120021119 0027-8424 https://hdl.handle.net/10356/164075 10.1073/pnas.2120021119 35881808 2-s2.0-85135100501 31 119 e2120021119 en 002479-00001 Proceedings of the National Academy of Sciences of the United States of America © 2022 the Author(s). Published by PNAS.This article is distributed under Creative CommonsAttribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND). application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Engineering::Mechanical engineering
2D-Layered Materials
Tandem Repeat Proteins
spellingShingle Engineering::Mechanical engineering
2D-Layered Materials
Tandem Repeat Proteins
Vural, Mert
Mazeed, Tarek
Li, Dong
Colak, Oguzhan
Hamilton, Reginald F.
Gao, Huajian
Demirel, Melik C.
Bioinspired stretchable molecular composites of 2D-layered materials and tandem repeat proteins
description Protein based composites, such as nacre and bone, show astounding evolutionary capabilities, including tunable physical properties. Inspired by natural composites, we studied assembly of atomistically thin inorganic sheets with genetically engineered polymeric proteins to achieve mechanically compliant and ultra-tough materials. Although bare inorganic nanosheets are brittle, we designed flexible composites with proteins, which are insensitive to flaws due to critical structural length scale (∼2 nm). These proteins, inspired by squid ring teeth, adhere to inorganic sheets via secondary structures (i.e., β-sheets and α-helices), which is essential for producing high stretchability (59 ± 1% fracture strain) and toughness (54.8 ± 2 MJ/m3). We find that the mechanical properties can be optimized by adjusting the protein molecular weight and tandem repetition. These exceptional mechanical responses greatly exceed the current state-of-the-art stretchability for layered composites by over a factor of three, demonstrating the promise of engineering materials with reconfigurable physical properties.
author2 School of Mechanical and Aerospace Engineering
author_facet School of Mechanical and Aerospace Engineering
Vural, Mert
Mazeed, Tarek
Li, Dong
Colak, Oguzhan
Hamilton, Reginald F.
Gao, Huajian
Demirel, Melik C.
format Article
author Vural, Mert
Mazeed, Tarek
Li, Dong
Colak, Oguzhan
Hamilton, Reginald F.
Gao, Huajian
Demirel, Melik C.
author_sort Vural, Mert
title Bioinspired stretchable molecular composites of 2D-layered materials and tandem repeat proteins
title_short Bioinspired stretchable molecular composites of 2D-layered materials and tandem repeat proteins
title_full Bioinspired stretchable molecular composites of 2D-layered materials and tandem repeat proteins
title_fullStr Bioinspired stretchable molecular composites of 2D-layered materials and tandem repeat proteins
title_full_unstemmed Bioinspired stretchable molecular composites of 2D-layered materials and tandem repeat proteins
title_sort bioinspired stretchable molecular composites of 2d-layered materials and tandem repeat proteins
publishDate 2023
url https://hdl.handle.net/10356/164075
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