ZAP isoforms regulate unfolded protein response and epithelial- mesenchymal transition

• Main Authors: Ly, Phuong Thao, Xu, Shaohai, Wirawan, Melissa, Luo, Dahai, Roca, Xavier
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Alternative Splicing; Unfolded Protein Response
• Online Access: https://hdl.handle.net/10356/164082
• Institution: Nanyang Technological University

Human ZAP inhibits many viruses, including HIV and coronaviruses, by binding to viral RNAs to promote their degradation and/or translation suppression. However, the regulatory role of ZAP in host mRNAs is largely unknown. Two major alternatively spliced ZAP isoforms, the constitutively expressed ZAP...