Doppelgänger spotting in biomedical gene expression data

• Main Authors: Wang, Li Rong, Choy, Xin Yun, Goh, Wilson Wen Bin
• Other Authors: School of Computer Science and Engineering
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Engineering::Computer science and engineering; Bioinformatics; Genomics
• Online Access: https://hdl.handle.net/10356/164208
• Institution: Nanyang Technological University

Doppelgänger effects (DEs) occur when samples exhibit chance similarities such that, when split across training and validation sets, inflates the trained machine learning (ML) model performance. This inflationary effect causes misleading confidence on the deployability of the model. Thus, so far, th...