Efficient recall of SARS-CoV-2 variant-reactive B cells and T responses in the elderly upon heterologous mRNA vaccines as boosters

• Main Authors: Rouers, Angeline, Wong, Nathan, Goh, Yun Shan, Torres-Ruesta, Anthony, Tay, Matthew Zirui, Chang, Zi Wei, Fong, Siew-Wai, Neo, Vanessa, Kam, Isaac Kai Jie, Yeo, Nicholas Kim-Wah, Huang, Yuling, Loh, Chiew Yee, Hor, Pei Xiang, Wong, Joel Xu En, Tan, Yong Jie, Macary, Paul A., Qian, Xinlei, Bei, Wang, Ngoh, Eve Zi Xian, Salleh, Siti Nazihah Mohd, Wang, Cheng-I, Poh, Xuan Ying, Rao, Suma, Chia, Po Ying, Ong, Sean W. X., Lee, Tau Hong, Lin, Ray J. H., Lim, Clarissa, Teo, Jefanie, Ren, Ee Chee, Lye, David C., Young, Barnaby Edward, Ng, Lisa F. P., Renia, Laurent
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; B Cell; Humoral Immunity
• Online Access: https://hdl.handle.net/10356/164318
• Institution: Nanyang Technological University

Waning antibody levels against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the emergence of variants of concern highlight the need for booster vaccinations. This is particularly important for the elderly population, who are at a higher risk of developing severe coronavirus disea...