Dissecting the role of diabetes-associated PAX4 polymorphisms in modulating pancreatic beta cell development and function

Diabetes is a major chronic disease with an excessive healthcare burden on society. A missense variant within the coding region of the PAX4 gene (rs2233580, R192H) is associated with T2D in East Asians. In mice, Pax4 is essential for beta cell formation but neither the role of diabetes associate...

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Bibliographic Details
Main Author: Lau, Hwee Hui
Other Authors: Tan Nguan Soon
Format: Thesis-Doctor of Philosophy
Language:English
Published: Nanyang Technological University 2023
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Online Access:https://hdl.handle.net/10356/164374
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Institution: Nanyang Technological University
Language: English