MCI-frcnn: a deep learning method for topological micro-domain boundary detection

• Main Authors: Tian, Simon Zhongyuan, Yin, Pengfei, Jing, Kai, Yang, Yang, Xu, Yewen, Huang, Guangyu, Ning, Duo, Fullwood, Melissa Jane, Zheng, Meizhen
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Deep Learning; Topological Micro-Domain
• Online Access: https://hdl.handle.net/10356/164518
• Institution: Nanyang Technological University

Chromatin structural domains, or topologically associated domains (TADs), are a general organizing principle in chromatin biology. RNA polymerase II (RNAPII) mediates multiple chromatin interactive loops, tethering together as RNAPII-associated chromatin interaction domains (RAIDs) to offer a framew...