Tetrad-binding ligands do not bind specifically to left-handed G-quadruplexes

G-quadruplexes (G4s) are attractive anticancer targets. While right-handed G4s have been extensively investigated with many specific ligands reported, left-handed G4s formed by natural DNA have been recently discovered. Here we show that ligands specific for right-handed G4s, such as Phen-DC3 and RH...

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Bibliographic Details
Main Authors: Das, Poulomi, Phan, Anh Tuân
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2023
Subjects:
DNA
Online Access:https://hdl.handle.net/10356/164741
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Institution: Nanyang Technological University
Language: English