In vivo positron emission tomography imaging of mitochondrial abnormalities in a mouse model of tauopathy

• Main Authors: Barron, Anna M., Ji, Bin, Fujinaga, Masayuki, Zhang, Ming-Rong, Suhara, Tetsuya, Sahara, Naruhiko, Aoki, Ichio, Tsukada, Hideo, Higuchi, Makoto
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences::Biochemistry; Functional Neuroimaging; Alzheimer's Disease
• Online Access: https://hdl.handle.net/10356/164795
• Institution: Nanyang Technological University

Damaged mitochondria may be one of the earliest manifestations of Alzheimer`s disease (AD). Since oxidative phosphorylation is a primary source of neuronal energy, unlike glycolysis-dependent energy production in inflamed glia, mitochondrial respiration could provide a selective biomarker of neurona...