Feedback inhibition underlies new computational functions of cerebellar interneurons

• Main Authors: Halverson, Hunter E., Kim, Jinsook, Khilkevich, Andrei, Mauk, Michael D., Augustine, George James
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Molecular Layer Interneurons; Feedback Inhibition; Cerebellar Learning
• Online Access: https://hdl.handle.net/10356/164830
• Institution: Nanyang Technological University

The function of a feedback inhibitory circuit between cerebellar Purkinje cells and molecular layer interneurons (MLIs) was defined by combining optogenetics, neuronal activity recordings both in cerebellar slices and in vivo, and computational modeling. Purkinje cells inhibit a subset of MLIs in th...