Optogenetic Visualization of Presynaptic Tonic Inhibition of Cerebellar Parallel Fibers

Optogenetic Visualization of Presynaptic Tonic Inhibition of Cerebellar Parallel Fibers

Tonic inhibition was imaged in cerebellar granule cells of transgenic mice expressing the optogenetic chloride indicator, Clomeleon. Blockade of GABAA receptors substantially reduced chloride concentration in granule cells due to block of tonic inhibition. This indicates that tonic inhibition is a s...

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Bibliographic Details
Main Authors: Berglund, Ken, Wen, Lei, Dunbar, Robert L., Feng, Guoping, Augustine, George James
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2016
Subjects:
Tonic inhibition
Parallel fibers
Online Access:https://hdl.handle.net/10356/81981
http://hdl.handle.net/10220/41039
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/81981
http://hdl.handle.net/10220/41039

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