Optogenetic Visualization of Presynaptic Tonic Inhibition of Cerebellar Parallel Fibers

• المؤلفون الرئيسيون: Berglund, Ken, Wen, Lei, Dunbar, Robert L., Feng, Guoping, Augustine, George James
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2016
• الموضوعات: Tonic inhibition; Parallel fibers
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/81981; http://hdl.handle.net/10220/41039

Tonic inhibition was imaged in cerebellar granule cells of transgenic mice expressing the optogenetic chloride indicator, Clomeleon. Blockade of GABAA receptors substantially reduced chloride concentration in granule cells due to block of tonic inhibition. This indicates that tonic inhibition is a s...