Optogenetic Visualization of Presynaptic Tonic Inhibition of Cerebellar Parallel Fibers

• Main Authors: Berglund, Ken, Wen, Lei, Dunbar, Robert L., Feng, Guoping, Augustine, George James
• 其他作者: Lee Kong Chian School of Medicine (LKCMedicine)
• 格式: Article
• 語言: English
• 出版: 2016
• 主題: Tonic inhibition; Parallel fibers
• 在線閱讀: https://hdl.handle.net/10356/81981; http://hdl.handle.net/10220/41039

Tonic inhibition was imaged in cerebellar granule cells of transgenic mice expressing the optogenetic chloride indicator, Clomeleon. Blockade of GABAA receptors substantially reduced chloride concentration in granule cells due to block of tonic inhibition. This indicates that tonic inhibition is a s...