Optogenetic Visualization of Presynaptic Tonic Inhibition of Cerebellar Parallel Fibers

• Main Authors: Berglund, Ken, Wen, Lei, Dunbar, Robert L., Feng, Guoping, Augustine, George James
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2016
• Subjects: Tonic inhibition; Parallel fibers
• Online Access: https://hdl.handle.net/10356/81981; http://hdl.handle.net/10220/41039
• Institution: Nanyang Technological University

Tonic inhibition was imaged in cerebellar granule cells of transgenic mice expressing the optogenetic chloride indicator, Clomeleon. Blockade of GABAA receptors substantially reduced chloride concentration in granule cells due to block of tonic inhibition. This indicates that tonic inhibition is a s...