Autotaxin signaling facilitates β cell dedifferentiation and dysfunction induced by Sirtuin 3 deficiency

• Main Authors: Cao, Huanyi, Chung, Arthur C. K., Ming, Xing, Mao, Dandan, Lee, Heung Man, Cao, Xiaoyun, Rutter, Guy A., Chan, Juliana C. N., Tian, Xiao Yu, Kong, Alice P. S.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Autotaxin; Lysophosphatidic Acid
• Online Access: https://hdl.handle.net/10356/164865
• Institution: Nanyang Technological University

Objective: β cell dedifferentiation may underlie the reversible reduction in pancreatic β cell mass and function in type 2 diabetes (T2D). We previously reported that β cell-specific Sirt3 knockout (Sirt3f/f;Cre/+) mice developed impaired glucose tolerance and glucose-stimulated insulin secretion af...