Going beyond the scratched surface with In situ self-assembly: protease activated developments for imaging and therapy
As the manifestation of most diseases originate from molecular malfunctions too insignificant to be detectable by existing diagnostic techniques, irregular molecular-level events such as the overexpression of a disease-related protease can be amplified by inducing an aggregation or accumulation t...
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| Format: | Thesis-Doctor of Philosophy |
| Language: | English |
| Published: |
Nanyang Technological University
2023
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| Online Access: | https://hdl.handle.net/10356/164935 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | As the manifestation of most diseases originate from molecular malfunctions too
insignificant to be detectable by existing diagnostic techniques, irregular molecular-level
events such as the overexpression of a disease-related protease can be amplified by
inducing an aggregation or accumulation to better facilitate early detection and
treatment. This thesis hence explores different novel and interesting mechanisms on
how the innate overexpression of furin, a particular disease-related protease of interest,
can be exploited as an endogenous stimulus for tumor site-specific self-assembly to
largely amplify minute irregularities in the tumor microenvironment, bringing about a
drastic difference in effect between tumor and normal cells. |
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