Going beyond the scratched surface with In situ self-assembly: protease activated developments for imaging and therapy

As the manifestation of most diseases originate from molecular malfunctions too insignificant to be detectable by existing diagnostic techniques, irregular molecular-level events such as the overexpression of a disease-related protease can be amplified by inducing an aggregation or accumulation t...

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Main Author: Kwek, Germain Jia Min
Other Authors: Xing Bengang
Format: Thesis-Doctor of Philosophy
Language:English
Published: Nanyang Technological University 2023
Subjects:
Online Access:https://hdl.handle.net/10356/164935
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1649352023-03-06T07:30:04Z Going beyond the scratched surface with In situ self-assembly: protease activated developments for imaging and therapy Kwek, Germain Jia Min Xing Bengang School of Chemistry, Chemical Engineering and Biotechnology Bengang@ntu.edu.sg Science::Chemistry::Biochemistry As the manifestation of most diseases originate from molecular malfunctions too insignificant to be detectable by existing diagnostic techniques, irregular molecular-level events such as the overexpression of a disease-related protease can be amplified by inducing an aggregation or accumulation to better facilitate early detection and treatment. This thesis hence explores different novel and interesting mechanisms on how the innate overexpression of furin, a particular disease-related protease of interest, can be exploited as an endogenous stimulus for tumor site-specific self-assembly to largely amplify minute irregularities in the tumor microenvironment, bringing about a drastic difference in effect between tumor and normal cells. Doctor of Philosophy 2023-02-28T11:47:48Z 2023-02-28T11:47:48Z 2023 Thesis-Doctor of Philosophy Kwek, G. J. M. (2023). Going beyond the scratched surface with In situ self-assembly: protease activated developments for imaging and therapy. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/164935 https://hdl.handle.net/10356/164935 10.32657/10356/164935 en This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). application/pdf Nanyang Technological University
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Chemistry::Biochemistry
spellingShingle Science::Chemistry::Biochemistry
Kwek, Germain Jia Min
Going beyond the scratched surface with In situ self-assembly: protease activated developments for imaging and therapy
description As the manifestation of most diseases originate from molecular malfunctions too insignificant to be detectable by existing diagnostic techniques, irregular molecular-level events such as the overexpression of a disease-related protease can be amplified by inducing an aggregation or accumulation to better facilitate early detection and treatment. This thesis hence explores different novel and interesting mechanisms on how the innate overexpression of furin, a particular disease-related protease of interest, can be exploited as an endogenous stimulus for tumor site-specific self-assembly to largely amplify minute irregularities in the tumor microenvironment, bringing about a drastic difference in effect between tumor and normal cells.
author2 Xing Bengang
author_facet Xing Bengang
Kwek, Germain Jia Min
format Thesis-Doctor of Philosophy
author Kwek, Germain Jia Min
author_sort Kwek, Germain Jia Min
title Going beyond the scratched surface with In situ self-assembly: protease activated developments for imaging and therapy
title_short Going beyond the scratched surface with In situ self-assembly: protease activated developments for imaging and therapy
title_full Going beyond the scratched surface with In situ self-assembly: protease activated developments for imaging and therapy
title_fullStr Going beyond the scratched surface with In situ self-assembly: protease activated developments for imaging and therapy
title_full_unstemmed Going beyond the scratched surface with In situ self-assembly: protease activated developments for imaging and therapy
title_sort going beyond the scratched surface with in situ self-assembly: protease activated developments for imaging and therapy
publisher Nanyang Technological University
publishDate 2023
url https://hdl.handle.net/10356/164935
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