Going beyond the scratched surface with In situ self-assembly: protease activated developments for imaging and therapy
As the manifestation of most diseases originate from molecular malfunctions too insignificant to be detectable by existing diagnostic techniques, irregular molecular-level events such as the overexpression of a disease-related protease can be amplified by inducing an aggregation or accumulation t...
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2023
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sg-ntu-dr.10356-1649352023-03-06T07:30:04Z Going beyond the scratched surface with In situ self-assembly: protease activated developments for imaging and therapy Kwek, Germain Jia Min Xing Bengang School of Chemistry, Chemical Engineering and Biotechnology Bengang@ntu.edu.sg Science::Chemistry::Biochemistry As the manifestation of most diseases originate from molecular malfunctions too insignificant to be detectable by existing diagnostic techniques, irregular molecular-level events such as the overexpression of a disease-related protease can be amplified by inducing an aggregation or accumulation to better facilitate early detection and treatment. This thesis hence explores different novel and interesting mechanisms on how the innate overexpression of furin, a particular disease-related protease of interest, can be exploited as an endogenous stimulus for tumor site-specific self-assembly to largely amplify minute irregularities in the tumor microenvironment, bringing about a drastic difference in effect between tumor and normal cells. Doctor of Philosophy 2023-02-28T11:47:48Z 2023-02-28T11:47:48Z 2023 Thesis-Doctor of Philosophy Kwek, G. J. M. (2023). Going beyond the scratched surface with In situ self-assembly: protease activated developments for imaging and therapy. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/164935 https://hdl.handle.net/10356/164935 10.32657/10356/164935 en This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). application/pdf Nanyang Technological University |
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Science::Chemistry::Biochemistry Kwek, Germain Jia Min Going beyond the scratched surface with In situ self-assembly: protease activated developments for imaging and therapy |
description |
As the manifestation of most diseases originate from molecular malfunctions too
insignificant to be detectable by existing diagnostic techniques, irregular molecular-level
events such as the overexpression of a disease-related protease can be amplified by
inducing an aggregation or accumulation to better facilitate early detection and
treatment. This thesis hence explores different novel and interesting mechanisms on
how the innate overexpression of furin, a particular disease-related protease of interest,
can be exploited as an endogenous stimulus for tumor site-specific self-assembly to
largely amplify minute irregularities in the tumor microenvironment, bringing about a
drastic difference in effect between tumor and normal cells. |
author2 |
Xing Bengang |
author_facet |
Xing Bengang Kwek, Germain Jia Min |
format |
Thesis-Doctor of Philosophy |
author |
Kwek, Germain Jia Min |
author_sort |
Kwek, Germain Jia Min |
title |
Going beyond the scratched surface with In situ self-assembly: protease activated developments for imaging and therapy |
title_short |
Going beyond the scratched surface with In situ self-assembly: protease activated developments for imaging and therapy |
title_full |
Going beyond the scratched surface with In situ self-assembly: protease activated developments for imaging and therapy |
title_fullStr |
Going beyond the scratched surface with In situ self-assembly: protease activated developments for imaging and therapy |
title_full_unstemmed |
Going beyond the scratched surface with In situ self-assembly: protease activated developments for imaging and therapy |
title_sort |
going beyond the scratched surface with in situ self-assembly: protease activated developments for imaging and therapy |
publisher |
Nanyang Technological University |
publishDate |
2023 |
url |
https://hdl.handle.net/10356/164935 |
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1759855803219574784 |