Functional analysis of germline RAD51C missense variants highlight the role of RAD51C in replication fork protection

Functional analysis of germline RAD51C missense variants highlight the role of RAD51C in replication fork protection

Monoallelic or biallelic RAD51C germline mutations results in chromosome instability disorders such as fanconi anemia (FA) and cancers. The bona fide function of RAD51C is to assist RAD51 nucleoprotein filament onto single strand DNA to complete Homologous Recombination (HR) repair. In addition to H...

Full description

Saved in:
Bibliographic Details
Main Authors: Kolinjivadi, Arun Mouli, Chong, Siao Ting, Choudhary, Ramveer, Sankar, Haresh, Chew, Ee Ling, Yeo, Claresta, Chan, Sock Hoai, Ngeow, Joanne
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2023
Subjects:
Science::Medicine
Replication Fork
Genome Instability
Online Access:https://hdl.handle.net/10356/164979
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/164979

Similar Items